Background:
@EN This study was purposed to study the effect of reoxygenation with room air as compared to FiO2 1.0 in a feline model subjected to hypoxemia followed by reoxygenation. Changes in the brain energy metabolism were investigated by 31P magnetic
resonance
pectroscopy(31P MRS).
@ES Methods:
@EN Twelve cats wee employed for this study and divided into two groups(6 cats each). Both groups were subjected to hypoxemia for 1 hr with FiO2 0.07 followed by reoxygenation for 2hrs. For group 1, the reoxygenation was done FiO2 1.0 and for
group
2 by
room air. Brain intracellular pH and the ratio of Pcr/Pi(phosphocreatine/inorganic phosphate) were calculated from the spectra acquired every 15 minutes of the hypoxemia and reoxygenation periods.
@ES Results:
@EN The intracellular pH of the baseline were 7.07±0.01 and 7.04±0.01 for group 1 and group 2, respectively, and dropped to 6.89±0.04 and 6.83±0.06 during hypoxemia. For both groups, the intracellular pH returned to baseline values after 30
minutes
of reoxygenation. The ratios of Pcr/Pi of the baseline were 2.41±0.21 and 2.47±0.15, for group 1 and group 2, and dropped to 0.77±0.10 and 0.70±0.11, respectively, during hypoxemia and recovered to the baseline values after 30 minutes of
reoxygenation for the groups. For both groups. For both pH and the ratios of Pcr/Pi, the differences between the groups were statistically insignificant.
@ES Conclusions:
@EN From this study, we can conclude that reoxygenation by room air is as effective as FiO2 1.0 in the feline model of hypoxemia investigated by 31P MRS. (Korean J Anesthesiol 1996; 30: 509~515_
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